[Hiring] Structural Evolutionary Biologist @Invivyd
This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description We are seeking a Structural Evolutionary Biologist to join Invivyd’s Research and Development Team. The ideal candidate brings a strong foundation in molecular evolution, protein structure and computational analysis, with the ability to translate large-scale sequence data into mechanistic insights that inform therapeutic monoclonal antibody development.
- Lead an effort that coordinates inputs from microbiologists, evolutionary biologists and antibody engineers to guide programming efforts to develop bioinformatic tools for use in antibody discovery and development
- Analyze large sequence datasets to identify evolutionary trends, structural constraints, variant hotspots, and functional motifs in multiple viral target proteins
- Develop, maintain, and optimize computational pipelines for sequence processing, structural prediction, phylogenetic analysis, and evolutionary modeling
- Curate wastewater and clinical sequence database connectivity pipelines
- Support protein engineering and antibody programs by providing structural and evolutionary risk assessments and actionable insights
- Generate figures and animations that effectively communicate observed trends in virus evolution and target structural dynamics
- Author non-clinical study reports related to pathogen surveillance in support of regulatory filings
- Serve as primary point of contact for collaborations and contracts with external partners
- Manage a team of programmers and developers
- Collaborate closely with cross-functional teams, including other research and development groups, preclinical, clinical and regulatory teams
Qualifications
- PhD in a relevant scientific discipline (e.g., Computational Biology, Evolutionary Biology, Molecular Biology, Structural Biology, Biochemistry, Immunology, Microbiology)
- Demonstrated expertise in microbial molecular evolution, sequence analysis, and phylogenetics
- Experience working with large biological data sets and establishing quality assessment workflows for regularly updated databases
- Programming skills in Python and JavaScript
- Proficiency in design and maintenance of customized computational biology tools and cloud-based bioinformatics suites
- Experience in managing CROs and external collaborations, including budgeting and timeline management
- Strong problem-solving skills and the ability to adapt to evolving project needs
- Excellent verbal and written communication skills
- Ability to work independently as well as part of a multidisciplinary team
- Highly organized with strong attention to detail
- Inclusion of a coding portfolio as part of the application (a link to GitHub repository is preferred)
- At least 2 years of experience in the pharmaceutical or biotechnology industry, with a focus on antibody drug discovery and development or infectious diseases - preferred
- Experience with SARS-CoV-2 research or similar virology-related projects - preferred
- Experience in regulatory interactions and patenting strategies - preferred
Company Description
At Invivyd, Inc., we take those numbers very seriously and we come to work each day on a mission to deliver protection from serious viral infectious diseases, beginning with SARS-CoV-2. Invivyd deploys a proprietary integrated technology platform unique in the industry designed to assess, monitor, develop, and adapt to create best in class antibodies.
- In March 2024, Invivyd received emergency use authorization (EUA) from the U.S. FDA for a monoclonal antibody (mAb) in its pipeline of innovative antibody candidates.
- In October 2025, the FDA cleared the company's Investigational New Drug (IND) application and provided feedback to advance the company's REVOLUTION clinical program, Invivyd's development program for VYD2311, a vaccine alternative monoclonal antibody being investigated for the prevention of COVID-19.
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