[Remote] Clinical Director, Oncology Clinical Development

Note: The job is a remote job and is open to candidates in USA. Natera is seeking an experienced Clinical Director, Oncology Clinical Development to provide medical and scientific leadership for Natera-sponsored oncology clinical trials focused on minimal residual disease (MRD). In this pivotal role, you’ll drive the design and execution of biomarker-driven interventional and randomized studies that integrate MRD testing into precision oncology strategies.

Responsibilities

• Serve as the program-level medical lead for Natera-sponsored MRD clinical trials across assigned oncology indications, with ultimate accountability for clinical outcomes, data integrity, and patient safety
• Define clinical development strategies that align study design, endpoints, and execution with regulatory and scientific objectives
• Provide medical oversight across the full trial lifecycle, from design and protocol development through first patient in (FPI), data readout, and study close-out
• Provide strategic and medical guidance to Clinical Scientists, fostering collaboration on protocol design, data interpretation, and translational insights that drive clinical program success
• Act as Medical Monitor, overseeing safety signal detection, adverse event review, and risk mitigation in compliance with GCP and regulatory requirements
• Partner cross-functionally with Clinical Science, Clinical Operations, Data Management and Biostatistics to ensure timely and successful study execution, operational feasibility, and data quality
• Collaborate with Regulatory Affairs to support submissions, regulatory interactions, and responses, as appropriate
• Represent Natera as the clinical development lead in interactions with investigators, key opinion leaders, IRBs, and regulatory authorities
• Guide interpretation of interim and final analyses, ensuring scientific accuracy and clinical relevance
• Provide strategic leadership for clinical study reports, and other required study-related clinical and regulatory documentation in collaboration with cross-functional partners
• Lead authorship and strategy for manuscripts, abstracts, and conference presentations in collaboration with Clinical Science, Biostatistics, Translational Medicine and Scientific Communications
• Shape and influence the evolution of Natera’s Clinical Development organization by establishing governance standards, decision frameworks, and best practices that ensure high-quality, audit-ready execution across sponsored studies
• Provide senior-level mentorship and clinical leadership to Clinical Scientists, enabling consistent application of scientific rigor and regulatory standards across clinical programs

Skills

• MD (or equivalent)
• ≥3 years of industry experience in oncology clinical development
• Demonstrated experience serving as Medical Monitor or clinical lead for Phase II–III studies
• Strong working knowledge of GCP, ICH guidelines, and regulatory expectations for interventional trials
• Proven ability to interpret and communicate complex clinical data to internal and external stakeholders
• Board certification in Medical Oncology or Hematology/Oncology
• Experience with biomarker-driven development, molecular diagnostics, or MRD-focused programs
• Prior involvement in regulatory interactions (e.g., FDA meetings, briefing documents)
• Experience working within matrixed clinical development organizations

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
• Natera employees and their immediate families receive free testing
• Fertility care benefits
• Pregnancy and baby bonding leave
• 401k benefits
• Commuter benefits
• Generous employee referral program

Company Overview

Company H1B Sponsorship